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Studies have shown that the overexpression of CTLA - 4 significantly reduces the area of atherosclerotic lesions and decreases the infiltration of macrophages and CD4 + T cells within plaques via mechanisms involving the inhibition of CD4 + T cell proliferation, downregulation of CD80/CD86 expression, and suppression of T cell activation (113)

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Pharmaceutically important pre- and posttranslational modifications on human serum albumin

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