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Copyright: 2024 Arumugam A, et al

Chronic hyperglycemia leads to accumulation of advanced glycation end products (AGEs) in bone collagen, reducing bone material properties and increasing brittleness

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The most commonly reported side effects in the Phase 2 trial were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and most prominent during dose escalation

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