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Supports recovery: L-Carnitine may help reduce post-exercise fatigue and muscle soreness, supporting quicker recovery after intense training
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
Testosterone replacement therapy is exact
Clinical studies suggest collagen supplementation may help: reduce knee osteoarthritis pain improve joint function support tendon rehabilitation when combined with exercise Examples of Osteoarthritis studies: Examples of Tendon studies: Unlike injectable peptides, collagen supplements function as nutritional support, not pharmacologic signaling molecules
Emerging evidence suggests that MetS contributes to pain catastrophizing, with obesity acting as a key amplifier of pain perception in inflammatory diseases such as PsA (73)
Researchers should always be wary of any post-hoc theories to justify an observed correlation as practical experience has shown that researchers can easily suggest a plausible rationale
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