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Guidelines recommend glucagonlike peptide-1 receptor agonist (GLP-1RA) and/or sodium-glucose cotransporter 2 inhibitor (SGLT2i) as initial pharmacologic therapy in people with T2D and ASCVD or high risk for ASCVD, heart failure, or CKD for comprehensive cardiovascular (CV) and renal risk management
Tirzepatide (Mounjaro, Zepbound) produces around 20.9% body weight loss at 72 weeks in the SURMOUNT-1 trial
doi: 10.1016/j.peptides.2017.11.021 115 GasbjergLSBariEJChristensenMKKnopFK
Your body loses some of its adaptation to the medication during extended breaks, and jumping back to a full dose can cause significant nausea and vomiting that would not have occurred if you had maintained the schedule
Increased levels of TGF- have been demonstrated to decrease expression of GCLC, essential for the rate-limiting step of the de novo synthesis of GSH
Evans et al
