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Three downstream mechanisms drive the loss: Severe appetite suppression cuts total calories

Liraglutide and tirzepatide are effective for weight loss but have a poorer safety profile and higher discontinuation rates due to adverse events

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GI side effects are some of the most common for semaglutide, with diarrhea occurring for about 30% of semaglutide users, vomiting for 24.5%, and nausea for about 43.9%

By February 2025 for semaglutide and March 2025 for tirzepatide, FDA declared both shortages resolved and transitional exemption windows ended

Its also worth keeping things in perspective: When people start a new medication, its natural to link any new symptom to that drug, whether or not its actually related, Dr