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It works by increasing tissue in the wound and helps close open wounds

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Wigren HK, Schepens M, Matto V, Stenberg D, Porkka-Heiskanen T (2007) Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep

Trends Cell Biol 26(3):165176

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Every time you draw solution from a vial without replacing the volume with air, you create negative pressure