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Figure 3 For experiment 4: Plasma levels of Atlas987 and paroxetine we used 12 adult male Wistar Unilever rats (3 months of age)
If no improvement appears after six months of consistent use, consider whether the protocol needs modification
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Although several PPI inhibitors with improved selectivity have recently been identified, using combined approaches that brought together protein crystallography, ligand NMR spectroscopy, and computational chemistry, unfortunately, none of them has been found to be able to cross the BBB and many are quite large in size and contain carboxylic acids, features which usually prevent or decrease CNS permeability [299]
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