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Malagn MM, Luque RM, Ruiz-Guerrero E, Rodrguez-Pacheco F, Garca-Navarro S, Casanueva FF, Gracia-Navarro F, Castao JP

Singh P, Vinikoor T, Sharma N, et al

Although the use of glucagon alone may not be favorable for weight management, combining it with other gut-pancreatic hormones (such as GLP-1) might represent a new direction in the development of drugs for obesity, aiming to balance blood sugar regulation with weight reduction

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The glucose-lowering effect of GLP-1 RAs primarily operates through stimulating insulin secretion, inhibiting glucagon release, and reducing hepatic glucose production