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In Phase 2 trials published in the *New England Journal of Medicine* (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks outperforming tirzepatide and semaglutide in head-to-head data comparisons

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Thus, glycocalyx disruption represents a central event linking endothelial dysfunction, oxidative stress, microthrombosis, and impaired vasoregulation in the complex pathophysiology of DCI (67, 70)

Multiple Benefits There is no denying the tremendous results from these medications

Its primary function is regulating actin, a structural protein essential to cell motility and tissue repair

Comparisons find both medications effective for sustained weight management