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Semaglutide also affects gastrointestinal motility more broadly, not just gastric emptying

NAC is plausible on top of that

Complementing these targeted analyses, a recent epigenome-wide association study demonstrated sex-specific DNA methylation changes and epigenetic age acceleration, including the differential methylation in both CRY2 and RORA, linking NSW to epigenetic alterations in circadian regulators 33

This potential benefit was confirmed for dapagliflozin in the recently published pivotal DAPA-HF (Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure) trial, which compared dapagliflozin with placebo in study participants on optimal standard heart failure therapy [5]

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