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10.1074/jbc.M305108200 92 NishidaM.HaradaS.NoguchiS.SatowY.InoueH.TakahashiK

The more severe health risks include: An increased risk of death from cardiovascular disease

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This initial step is crucial and can be impaired in individuals with reduced gastric acid production, such as older adults or those taking proton pump inhibitors (PPIs) or H2-receptor antagonists

Structure and regulation of glutathione S-transferase genes

If it has been stored at room temperature already (which is acceptable for certain formulations for limited periods), this step becomes less critical