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Certain disorders or health conditions like Crohns disease, celiac disease, or other intestinal disorders can mean it is more difficult for the body to absorb B12 from the food you eat

Patients should be advised that NHS-funded treatment duration is typically limited to a maximum of 2 years, as per NICE guidance, and that discontinuation often results in weight regain

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The once-weekly dosing and gradual dose escalation protocol may help minimise side effects

However, the literature does not yet provide a fully resolved primary molecular target, a unified causal mechanism, or sufficient controlled human evidence to support conclusions about therapeutic use