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Reduction of GSSG to two moles of GSH is the function of glutathione reductase, an enzyme that requires coupled oxidation of NADPH
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Methylcobalamin, on the other hand, skips that conversion and directly enters B12-dependent biochemical reactions
GLS is frequently overexpressed in various types of cancer, including TNBC, NSCLC, and acute myeloid leukemia ( Therefore, inhibiting Gln degradation by downregulating the expression of these enzymes may represent a novel strategy for cancer treatment
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