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Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort
Because fluoxetine does not trigger dopamine release in the reward pathway, it cannot produce the rush, high, or euphoria that motivates recreational drug use, and most attempts to misuse it yield no pleasurable or intoxicating effect whatsoever
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Available from www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/06/WC500129256.pdf
It is caused by the caloric restriction and rapid weight loss, which trigger a shift of hair follicles from the growth phase to the resting and shedding phase
Pulkkinen, M
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