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10.1021/acs.jmedchem.6b01031 67 KramrE
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When it comes to anti-doping and clean sport we are in serious trouble when giant retailers like Amazon are once again some of the largest purveyors of performance enhancing drugs on earth
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Fatty acids are utilized as an energy substrate in all tissues except the brain
Functioning independently of its canonical unfolded protein response role, the endoplasmic reticulum-resident protein IRE1 governs ferroptotic susceptibility through an evolutionarily conserved mechanism wherein its endoribonuclease activity degrades transcripts encoding glutathione biosynthesis factors GCLC and SLC7A11, rendering IRE1-deficient cells resistant while overexpressing cells hyper-sensitive to this death pathway (55)
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