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It is reported that IGF-1 promotes hepatocyte proliferation, differentiation, cell cycle progression, and prolonging survival 30,31,32 , suggested that IGF-1 might repress cell premature aging and repair intrahepatic cells to ameliorate liver diseases

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These cytokines can also cross the blood-brain barrier, driving the severe neuroinflammation responsible for the profound cognitive dysfunction, memory loss, and "brain fog" reported by so many patients

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The immediate activation of the adaptive ER stress response was reduced, but not blocked by GSTP1