The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
It is therefore not only important to learn how to spot the early signs and symptoms of the various forms of both melanoma and non-melanoma skin cancer, but to regularly check your skin for signs of change and to seek professional advice, whilst keeping track of anything that concerns you
If the score makes you tense, switch back to a paper diary for two weeks
[8] Guevara-Campos J, Gonzlez-Guevara L, Cauli O
Many supplements on the market contain synthetic fillers, artificial colors, or "flow agents" like magnesium stearate that add no nutritional value and may even interfere with absorption
Persistent symptoms warrant reassessment rather than automatic dose escalation