their accumulation at presynaptic terminals and postsynaptic dendritic spines is increased when the synaptic activity is elevated [31]
Key immunomodulatory actions include enhanced phagocytic activity of peripheral leukocytes, upregulated secretion of immunoglobulins (IgA, IgG, and IgM), and increased production of cytokines such as interleukins, TNF-, and interferon- (IFN-) (488)
Januel C, El Hentati FZ, Carreras M, Arthur JR, Calzada C, Lagarde M et al
But that is where the similarities end
Because they are not easily cleared, very high intakes can build up and cause toxicity
repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover