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Studies show patients on tirzepatide lost a higher percentage of body weight

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Selective ablation of NTS PPG neurons significantly reduces active GLP-1 levels in both the brain and spinal cord, suggesting that these neurons represent a major source of endogenous central GLP-1 ( In human brain tissue, GLP-1Rs have similarly been confirmed in neurons within the hypothalamus, medulla oblongata, and parietal cortex

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For example, acid reflux may just be acid reflux, or it could be a warning sign of gastroparesis