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Despite FAERS limitations (underreporting bias, confounding factors), these findings advocate for tailored monitoring protocolsgradual dose titration, renal/thyroid surveillance in high-risk groups, and long-term vigilance for rare AEs

2014 Dec;171(24):5696-707

However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study) evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatide was observed in high-risk diabetic subjects

Many patients notice reduced appetite and early satiety within the first week of treatment

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