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Relative risks were derived from meta-analyses of 38 randomized clinical trials

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Some people may continue the 5 mg dose long term

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In post-ischemic rat hearts, treatment with dapagliflozin results in higher level of IL-10, a cytokine that facilitates the conversion of macrophages from a pro-inflammatory M1 to anti-inflammatory M2 phenotype, thereby inhibiting myofibroblast differentiation and extracellular matrix formation (Lee et al., 2017)

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