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There are no established dosing protocols, treatment durations, or safety guidelines for human use
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Setting that expectation at the consult prevents most of the disappointment in this category
BMJ 352:i610 Aronoff S, Rosenblatt S, Braithwaite S et al (2000) Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study
You may need to restart titration from a lower dose to avoid GI side effects when re-introducing the drug
Always wear a broad-spectrum sunscreen, as UV exposure can trigger the melanin production you are trying to balance
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