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Even some meat eaters dont absorb it very well (4, Unlike other vitamins, the absorption of vitamin B12 depends on a protein produced in your stomach, called intrinsic factor

2, MTHFR catalyzes the physiologically irreversible reduction of 5,10-methylene THF to 5-methyltetrahydrofolate (5-methyl THF), and plays a critical role in one-carbon metabolism for the reaction of producing methyl groups to participate in epigenetic regulation 18

Toxicol Appl Pharmacol 391:114900

10.1194/jlr.M300462-JLR200

Some patients notice minor facial warmth or flushing as magnesium enters the bloodstream one of the mild, temporary IV therapy side effects that resolves on its own within minutes

It has never been FDA-approved as a drug for any indication, and the absence of a completed phase III trial program means rare, long-term adverse events (including any cancer signal) may not yet be fully characterized in the way they would be for an approved compound