However, once chronic NAC treatment was resumed (at approximately P134) in those mice that had received it before, working memory, cognitive flexibility (tested under NAC), and anhedonia (sucrose-preference, tested 1 day after NAC-treatment stopped) were improved in CD2-KO mice
N., Longnecker, R
Doing so can increase the risk of side effects like low blood sugar (especially if combined with other diabetes medications) or gastrointestinal upset
This gradual approach is designed to help reduce side effects, like nausea or digestive discomfort, and improve how well you tolerate the medication long-term
doi:10.1016/j.ijcard.2022.05.056 Tonhajzerova I, Sekaninova N, Bona Olexova L, Visnovcova Z
Off-label use simply means a provider is using a substance for a purpose other than its original intention, based on professional judgment and clinical evidence