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KPV inhibits NF-B, the transcription factor that activates pro-inflammatory gene expression in response to cytokine signaling

The researchers weren't sure why

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Characterized by persistent fatigue, post-exertional malaise, and cognitive dysfunction, ME/CFS affects approximately 1% of the global population, with a higher prevalence in women [1, 2]

(1991) Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit