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Sedation and tiredness were commonly reported with drugs targeting the opioid receptors (like naltrexone) and combination therapies that target both the opioid and monoamine systems (such as Contrave)
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The Wegovy formulation was specifically approved for weight loss in non-diabetic patients based on the STEP clinical trial program
doi: 10.2147/DMSO.S434499 29 SteinertREGearyNBeglingerC
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Despite extensive investment in MASH drug development, only one medication (resmetirom) has been officially approved for MASH treatment to date
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