Its about matching treatment to the cause of the deficiency
In laboratory studies, inhibiting NNMT has been investigated for effects on cellular NAD+ levels and adipocyte (fat-cell) metabolism
The improvement in energy is often noticeable because the body is able to quickly absorb the vitamin directly into the bloodstream, bypassing any digestive absorption issues
The people who found closer to 50% in their urine probably had a slight vitamin B12 deficiency, and some of the vitamin was stored for later use
Bioavailability: nearly 100%, bypasses GI absorption entirely Deficiency: first-line for pernicious anemia and malabsorption Dosing: weekly to monthly maintenance Prescription: yes, through Heally At home: yes, after provider guidance Daily tablets or lozenges
The overall risk appears to be very low, but the theoretical concern necessitates appropriate patient selection and informed consent