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Enzymatic catalysis of Phase I biotransformations[edit | edit source] The most important enzymes catalysing phase 1 reactions are hemoproteins showing a characteristic maximum at 450 nm cytochrome P450 responsible for the oxidation of about 75% of drugs

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586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques

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