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Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2.8 pounds (1.27 kg) more than those taking a placebo over an average of 23 weeks ( In short, it seems that alpha-lipoic acid has just a slight effect on weight loss in humans

Participants took 6 mg, 12 mg, 36 mg, or placebo for 72 weeks