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In addition, animal, observational, and genetic studies suggest benefits of GLP-1RAs in people with alcohol use disorder, although randomized trials have produced mixed results, with ongoing trials assessing their effectiveness in those with substance use disorders (SUDs) and mental illnesses
doi: 10.3389/fimmu.2022.865982 62 CoombesJLSiddiquiKRArancibia-CarcamoCVHallJSunCMBelkaidYet al
Furthermore, the influence of the microbiota encompasses a spectrum of RNA modifications, including 5-methylcytosine (m5C) RNA methylation 141,142 and the emerging N4-acetylcytidine (ac4C) RNA acetylation 143,144
3.1.2 Microbiota dysbiosis and depressive behaviors Escherichia and Enterococcus produce serotonin, while Bifidobacterium and Lactobacillus synthesize GABA (Socaa et al., 2021)
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