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Patients with rare genetic conditions affecting B12 metabolism are typically managed by specialists who may prescribe high-dose hydroxocobalamin
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Clinicians prescribing BPC-157 off-label do so based on preclinical data, mechanistic plausibility, and patient-reported outcomes, not a regulatory evidence package
While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]
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