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Key limitation: Orlistat works best with a disciplined low-fat diet

Its been shown that hyperglycemia causes an increase in oxidative stress

The process itself is simple, but small details such as preparation, timing, and technique make a significant difference to how effective and comfortable the injection feels

Diarrhea and abdominal discomfort : Alcohol can accelerate intestinal transit and cause osmotic diarrhea, while tirzepatide commonly causes diarrhea (rates vary by dose, ranging from approximately 7-17% in clinical trials)

On average, individuals can lose up to 15% of their body weight within a year

Survodutide weight loss was still trending downward at week 46, suggesting longer trials could narrow the gap