Concurrently, the accumulation of peroxidation products activates the Ras/Raf/MEK/ERK pathway in endometrial cells, upregulating matrix metalloproteinase (MMP-2/MMP-9) expression and causing excessive degradation of the extracellular matrix (ECM)
7,8 However, immediate and abrupt withdrawal from Zoloft is not recommended at any time, especially during pregnancy
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