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Kavita Sharma, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues used data from 1,145 participants in a multisite, international trial, in which participants with obesity-related HFpEF were randomly assigned (1:1) to once-weekly semaglutide (2.4 mg) or placebo for 52 weeks

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Most protocols run for 3 to 6 months, with periodic lab monitoring to track IGF-1 and metabolic markers

Whilst certain strains may support general digestive comfort, they should not be relied upon to eliminate medication side effects

83.5% of patients who received GLP-1s had a reduction of their HbA1c, while only 55.9% of those who received metformin did

Recommended dose: 2,000 to 4,000 IU daily for maintenance