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A landmark human trial published in Nature Medicine by Depommier and colleagues (2019) showed that pasteurized Akkermansia supplementation improved insulin sensitivity, reduced total cholesterol, and decreased body weight slightly in overweight and obese individuals over a three-month period
Without ingredient disclosure, evaluation remains limited
Other risk factors for B12 deficiency that may coexist include proton pump inhibitor or H2-antagonist use, vegan/vegetarian diets, previous bariatric surgery, pernicious anaemia, and other malabsorptive conditions
These medications activate receptors that help curb hunger and promote a sense of satiety, making it easier to stick to a balanced, calorie-conscious diet
A structured taper is not optional
As cardiologists, we believe SOUL trial benefits are very likely to apply to Indian patients, especially since Indians often develop diabetes, obesity, and heart disease at younger ages and lower BMI levels.Studies and the STEP-HFpEF trials suggest symptom and functional improvement with semaglutide in obesity-related heart failure
