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Semaglutide GLP-1 works by mimicking a natural hormone in the body called glucagon-like peptide-1 (GLP-1)

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Semaglutide works by slowing gastric emptying, meaning that it makes you feel fuller for longer, and it also improves communication between your stomach and your brain, so you feel fuller faster

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Indeed, the combined use of these medications is suggested to be synergistic and, as reported in a recent meta-analysis, superior outcomes with the addition of a GLP-1 RA to SGLT2i can be observed in type 2 diabetes, although observations of cardiovascular and mortality outcomes are limited [29]

Role of IGF-1 receptor in the regulation of cell metabolism