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For a regular patient with vitamin B12 deficiency, the doctors usually start with a high dosage

First, convert milligrams (mg) to micrograms (mcg): 10mg = 10,000mcg

Compared to control rats, MTX treatment resulted in substantial increases in AST, ALT, and ALP activities, as well as in the concentration of cholesterol, triacylglycerides, and LDL-cholesterol, and a reduction in the serum concentration of HDL-cholesterol

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For example acetaminophen (Tylenol) decreases glutathione levels in the body

doi: 10.1016/j.cell.2018.03.006 282 WangYHouLYuanXXuNZhaoSYangLet al