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Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor Brain Res Dev Brain Res 1991
This suppresses transcription of pro-inflammatory genes, reducing TNF-alpha production and IL-6 secretion
This suggests that the similar pattern of MAP1LC3A increase in AD compared to Iso-cBOs could be an indicator of increased iron level, potentially being related to increased ferroptosis vulnerability
EZH2 regulates ferroptosis by modulating genes related to iron death, such as ACSL4, SLC7A11, Ubiquitin-Specific Protease 10 (USP10), TFR2, and Atonal bHLH Transcription Factor 8 (ATOH8) [153,154,155,156,157]
The peptide proved effective across multiple delivery routes, demonstrating therapeutic flexibility
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