glp 1 and lymphedema Frontiers GLP-1 & Lipedema: Dr. Wright

While topical creams and treatments help on the surface, addressing hyperpigmentation at its root requires working at the cellular level

But like most stories, this one isn't just about a fish or a lizard

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

Its the sweet spot of effectiveness without overwhelming the bodys natural processes

Diabetes Obes Metab (2021) 23 Suppl 3:529

I can't say definitely