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[1] Body weight and composition can influence the volume of distribution for GLP-1 medications, potentially affecting elimination kinetics

At minimum, youd expect a GLP-1s to cause a significant air pocket in bariatric volumes, as patients who otherwise would have undergone surgery try medication

14 Two therapeutic strategies currently exist to overcome the short half-life of incretin hormones and pharmacologically augment the incretin effect: 1) inject GLP-1 receptor agonists that are resistant to degradation by the DPP-4 enzyme and 2) orally administer DPP-4 inhibitors that delay the enzymatic degradation of naturally secreted incretin hormones ( Figure 2 )

The microdosing approach Some clinicians are exploring microdosing of GLP-1 medications specifically for autoimmune patients

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They discovered that both patient groups exhibited signs of elevated oxidative stress