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In addition, all subjects attended four-weekly telephone follow-up visits with a healthcare assistant which aimed to reduce discontinuation and offer additional time to stabilise before subsequent dose escalation

Physiotherapists demonstrate targeted exercises focused on strengthening the joint and relieving pain

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In this setting, glutathione depletion acts as a critical sensitizing factor that links intracellular redox-buffering capacity to tissue-level ferroptotic spread, effectively transforming stochastic cell death into coordinated population-level contagion

Serious Side Effects Pancreatitis : Although rare, there is a risk of pancreatitis, which is inflammation of the pancreas

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