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Cell Rep 22(7):17601773

No head-to-head trials specifically studied the switching protocol

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Nausea, bowel movement changes such as constipation or diarrhea, abdominal pain, and gas are common

Triggers can include factors that disrupt the microbiome, dysregulate the immune system, impair metabolic health, or drive inflammation more broadly

A physician-supervised plan can help answer whether the medication is appropriate, which option fits the patients risk profile, what dose should be used, how quickly the dose should increase, what side effects should be expected, when the dose should be held or adjusted, how much protein the patient should eat, how muscle can be preserved, what labs should be tracked, and what long-term maintenance should look like