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Thus, in humans, GLP-1 action appears to be predominantly functional and anti-apoptotic rather than proliferative ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

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Los estudios en animales han mostrado riesgos potenciales para el desarrollo fetal, y los datos en humanos an son limitados

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However, a dose-dependent insulinotropic and glucagonostatic response is preserved in response to exogenous GLP-1 treatment and 6-week subcutaneous GLP-1 infusion was shown to improve HbA1c levels by 1.3% [18]

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