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These circadian clock genes significantly influence the adaptive ROS threshold across different circadian phases

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Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages (Hu et al., 2024), the activation of which can increase the production of PGE 2 (Chopra et al., 2019)

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