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Weight loss is typically somewhat less than with semaglutide (5-10% on average), but still clinically meaningful

He et al., 2018)

Due to its relatively short half-life, many research protocols split the total daily dose into two smaller administrations (e.g., morning and evening)

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Sydow K, Daiber A, Oelze M, Chen Z, August M, Wendt M, Ullrich V, Mulsch A, Schulz E, Keaney Jr JF, Stamler JS, Munzel T

The fibrogenesis shows varying degrees, from mild to intense, until the formation of dense bundles that give the appearance of a desmoplastic or sometimes neuroid lesion