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Kidney Problems: GLP-1 medications can sometimes affect kidney function, especially in people with pre-existing kidney disease
LC-MS analysis was done on a Waters SYNAPT quadrupole/time-of-flight mass spectrometer operated in positive ion electrospray mode
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Rotating between sites serves two purposes: it prevents lipodystrophy (localized fat changes at repeated injection points) and potentially affects absorption rates
In the obese trial cohort, 1 mg moved 24-hour ambulatory heart rate by +0.7 bpm at week 24 the peak of the heart-rate curve, and below the placebo arms +0.8. In a healthy lean Phase 1 group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
Serious side effects remain the same as with other Wegovy doses, including potential risks of pancreatitis, gallbladder problems, kidney problems, and diabetic retinopathy in patients with diabetes
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