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And both decline with age
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Telomerase rebuilds those caps, but most adult cells keep it switched off
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[14] A 2018 systematic review and meta-analysis of 12 randomized controlled trials found "supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects." The review also indicates that "the effect of ALC in younger subjects was not more effective than placebo in improving these symptoms." indicating a need for more research explaining the age/effect relation
"Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription"
