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Neuroprotective Effects: Some studies suggest that GLP-1 agonists may have neuroprotective properties, potentially reducing inflammation in the central nervous system

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The Massachusetts General Hospital published guidance emphasizing that the most effective strategy for preserving lean body mass during GLP-1 therapy involves combining a high-protein diet with consistent resistance exercise

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One such study found that GLP-1 elevates intracellular cAMP, subsequently activating protein kinase A (PKA), which in turn inhibits RhoA/ROCK signaling, resulting in the disassembly of glucotoxicity-induced stress fibers 6

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