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Reorganization of sections: methodology and results See the authors' detailed response to the review by George Gourzoulidis An estimated 537 million people were living with diabetes worldwide in 2021, and this number is expected to increase based on trends and future projections, suggesting that by 2045 the absolute number of people with diabetes will have increased by 46%

GLP-1 medications can help with weight loss by promoting feelings of fullness and reducing appetite, leading to an overall decrease in ones calorie intake

This loss of dopaminergic neurons is a primary pathological feature of PD and is strongly associated with abnormal -synuclein expression, which contributes to dopaminergic neuronal cell loss (Hglinger et al

In the phase 3 SELECT trial of Wegovy, the drug lowered major adverse cardiovascular events (MACEs) by 20%

This was initially observed anecdotally in patients on semaglutide, then confirmed in progressively more rigorous studies

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