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Unmeasured confounders, particularly lifestyle factors such as dietary patterns, physical activity levels, smoking status, and alcohol consumption, could influence both treatment selection and observed ocular outcomes

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"If newly identified safety signals are identified, the FDA will determine what, if any, actions are appropriate after a thorough review of available data." These actions may include requiring labeling changes or development of a Risk Evaluation and Mitigation Strategy, a program that helps ensure a medication's benefits outweigh its risks